Bachelor or Master level student needed for developing mathematical software in brain imaging

We welcome a Bachelor or Master level student to complete a thesis work in developing mathematical open source solutions for estimating the activity of the human brain. An important topic would be to develop code for filtering and pre-processing the measured signal, and to evaluate the outcome with experimental data. The goal will be to implement filtering algorithms in the interface, and test the impact of the filtering parameters on the quality of the source and connectivity estimates. Tuning the topic depending on one’s personal interests and skills will be possible. The outcome can be integrated in Zeffiro Interface (ZI) Matlab package.

Zeffiro Interface (ZI), is an open source code package constituting an accessible tool for finite element (FE) based forward and inverse simulations in EEG/MEG and can be used also in other bioelectromagnetical imaging applications targeting the brain.

It is recommended to have background studies in basic signal processing, linear algebra and Matlab programming, although it is not necessary to fulfill all these requirements.

Please contact: Associate Professor Sampsa Pursiainen, Faculty of Information Sciences, Tampere University (sampsa.pursiainen@tuni.fi) or Dr. Narayan Subramaniyam, Faculty of Biomedical Sciences and Engineering, Tampere University (narayan.subramaniyam@tuni.fi).

ZI is an open source code package constituting an accessible tool for finite element (FE) based forward and inverse simulations in EEG/MEG and can be used also in other bioelectromagnetical imaging applications targeting the brain. With ZI, one can segment a realistic multilayer geometry and generate a multi-compartment FE mesh, if triangular ASCII surface grids (in .DAT file format or .ASC file format) are available. A suitable surface segmentation can be produced, for example, with the FreeSurfer software suite. A folder containing multiple meshes FreeSurfer’s .ASC format can be built as a single segmentation via the ASCII import utility. A parcellation created with FreeSurfer

can be imported to enable distinguishing different brain regions and, thereby, analysing the connectivity of the brain function over a time series. Multiple compartments can be defined as active, allowing the analysis of the sub-cortical strucures. In each compartment, the orientation of the activity can be either normally constrained or unconstrained.

References:

He, Q., Rezaei, A., & Pursiainen, S. (2018). Zeffiro user interface for electromagnetic brain imaging: a GPU accelerated FEM tool for forward and inverse computations in Matlab. Neuroinformatics, In press, arXiv preprint arXiv:1811.07717.

Miinalainen, T., Rezaei, A., Us, D., Nüßing, A., Engwer, C., Wolters, C. H., & Pursiainen, S. (2019). A realistic, accurate and fast source modeling approach for the EEG forward problem. NeuroImage, 184, 56-67.